JOMPAC

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

EndNote Style
Index
Original Article
Advancements and challenges in Hashimoto’s thyroiditis research: a bibliometric analysis
Aims: Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disorder and a leading cause of hypothyroidism worldwide. This bibliometric analysis aims to provide a comprehensive overview of HT research trends, key contributors, and emerging themes by evaluating 1.309 articles published between 2004 and 2023. The study seeks to identify gaps, highlight advancements, and offer insights to guide future research efforts.
Methods: Data were collected from the Web of Science Core Collection database using the keyword "Hashimoto" and filtered by the "endocrinology metabolism" category. Bibliometric analysis was conducted using VOSviewer to visualize publication trends, keyword relationships, and collaboration networks. Citation metrics and publication outputs were analyzed to identify influential contributors and emerging research themes.
Results: The analysis revealed a steady growth in publications, peaking in 2021, with notable contributions from leading institutions and journals such as thyroid and Journal of Clinical Endocrinology & Metabolism. Dominant themes included autoimmune mechanisms, thyroid dysfunction, and the gut-thyroid axis. Emerging areas, such as microbiota-targeted interventions and personalized medicine, offer promising avenues for advancing HT research. However, regional disparities and conflicting findings in treatment strategies, including dietary interventions and supplementation, underscore the need for more robust studies.
Conclusion: HT research has achieved significant progress in understanding its pathogenesis and clinical management. Future efforts should focus on multidisciplinary, large-scale studies that integrate advanced technologies and address regional research gaps. By fostering global collaborations and embracing innovative approaches, the scientific community can improve patient outcomes and advance the field of HT research.


1. Sawin CT. History of Hashimoto’s disease: the heritage of Dr. Hakaru Hashimoto (1881-1934). Endocr J. 2002;49(4):399-403. doi:10.1507/endocrj.49.399
2. Ahmed R, Al-Shaikh S, Akhtar M. Hashimoto thyroiditis: a century later. Adv Anat Pathol. 2012;19(3):181-126. doi:10.1097/PAP.0b013e 3182534868
3. Zaletel K, Gaberscek S. Hashimoto's thyroiditis: from genes to the disease. Curr Genomics. 2011;12(8):576-588. doi:10.2174/138920211798120763
4. Radetti G. Clinical aspects of Hashimoto's thyroiditis.Endocr Dev. 2014; 26:158-170. doi:10.1159/000363162
5. Klubo-Gwiezdzinska J, Wartofsky L. Hashimoto thyroiditis: an evidence-based guide to etiology, diagnosis and treatment. Pol Arch Intern Med. 2022;132(3):16222. doi:10.20452/pamw.16222
6. Akamizu T, Amino N. Hashimoto’s Thyroiditis. In: Endotext. MDText.com, Inc., South Dartmouth (MA); 2000.
7. Caturegli P, De Remigis A, Rose NR. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev. 2014;13(4-5):391-397. doi:10.1016/j.autrev.2014.01.007
8. Kessler MM. Bibliographic coupling between scientific papers. Am Doc. 1963;14(1):10-25. doi:10.1002/asi.5090140103
9. Boyack KW, Klavans R. Co-citation analysis, bibliographic coupling, and direct citation: which citation approach represents the research front most accurately? J Am Soc Inf Sci Technol. 2010;61(12):2389-2404. doi:10.1002/asi.21419
10. Hu X, Chen Y, Shen Y, Tian R, Sheng Y, Que H. Global prevalence and epidemiological trends of Hashimoto’s thyroiditis in adults: a systematic review and meta-analysis. Front Public Health. 2022;10:1020709. doi:10. 3389/fpubh.2022.1020709
11. Ragusa F, Fallahi P, Elia G, et al. Hashimoto’s thyroiditis: epidemiology, pathogenesis, clinic and therapy. Best Pract Res Clin Endocrinol Metab. 2019;33(6):101367. doi:10.1016/j.beem.2019.101367
12. Pyzik A, Grywalska E, Matyjaszek-Matuszek B, Rolinski J. Immune disorders in Hashimoto’s thyroiditis: what do we know so far? J Immunol Res. 2015;2015:979167. doi:10.1155/2015/979167
13. Fernández-García V, González-Ramos S, Martín-Sanz P, Laparra JM, Boscá L. Beyond classic concepts in thyroid homeostasis: immune system and microbiota. Mol Cell Endocrinol. 2021;533:111333. doi:10. 1016/j.mce.2021.111333
14. Liu J, Qin X, Lin B, et al. Analysis of gut microbiota diversity in Hashimoto’s thyroiditis patients. BMC Microbiol. 2022;22(1):318. doi:10. 1186/s12866-022-02739-z
15. Lerner A, Aminov R, Matthias T. Intestinal dysbiotic transglutaminases are potential environmental drivers of systemic autoimmunogenesis. Front Microbiol. 2017;8(66.10):3389. doi:10.3389/fmicb.2017.00066
16. McLeod DS, Cooper DS. The incidence and prevalence of thyroid autoimmunity. Endocrine. 2012;42(2):252-265. doi:10.1007/s12020-012-9703-2
17. Pirola I, Rotondi M, Cristiano A, et al. Selenium supplementation in patients with subclinical hypothyroidism affected by autoimmune thyroiditis: results of the SETI study. Endocrinol Diabetes Nutr. 2020; 67(1):28-35. doi:10.1016/j.endinu.2019.03.018
18. Shin DY, Kim KJ, Kim D, Hwang S, Lee EJ. Low serum vitamin D is associated with anti-thyroid peroxidase antibody in autoimmune thyroiditis. Yonsei Med J. 2014;55(2):476-481. doi:10.3349/ymj.2014.55.2. 476
19. Nodehi M, Ajami A, Izad M, et al. Effects of vitamin D supplements on frequency of CD4+ T-cell subsets in women with Hashimoto’s thyroiditis: a double-blind placebo-controlled study. Eur J Clin Nutr. 2019;73(9):1236-1243. doi:10.1038/s41430-019-0395-z
Volume 6, Issue 1, 2025
Page : 57-65
_Footer