JOMPAC
Journal of Medicine and Palliative Care

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

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Original Article
The relationship between thyroid functions, vitamin B12, and lipid profiles across different BMI categories in adults
Abstract
Aims: Obesity is a multifactorial condition characterized by abnormal or excessive fat accumulation that adversely impacts health and disrupts various metabolic processes. This study aimed to assess thyroid function tests, vitamin B12 levels, and lipid profiles in normal, overweight, and obese adults, and to elucidate the correlation with body-mass index (BMI) values.
Methods: This study was planned as a retrospective descriptive cross-sectional study. Within the scope of the study, age, gender, occupation, history of chronic diseases, smoking, alcohol use and drug use; weight, height, BMI, blood pressure; TSH, free T3, free T4, total cholesterol, LDL-cholesterol, HDL-cholesterol, VLDL-cholesterol, triglyceride, fasting blood glucose, vitamin B12, folate, ferritin, serum iron level, iron binding capacity and whole blood parameter values were retrieved and recorded by reviewing health records retrospectively. Patients were grouped according to BMI values, and the relationships between obesity, sociodemographic characteristics and blood parameters were analyzed.
Results: A total of 539 patients were analyzed, with 63.6% identified as women. The average age of the patients was 36.88±13.75 years (range: 13-79), and the average BMI was 26.92±6.37 kg/m². Analysis revealed that 40% of patients were classified as normal weight, 30.1% as overweight, 26.1% as obese, and 3.8% as underweight based on BMI criteria. The classification of obesity indicates that class 1 obesity accounts for 59.7%, while class 2 and class 3 obesity each represent 20.1% of the total cases. The obesity rate was 72.1% in women and 27.9% in men, with a statistically significant difference observed between genders and BMI groups (p<0.001). The prevalence of B12 deficiency was 1.2%, and no significant association was observed among BMI groups. The study identified a statistically significant difference in total cholesterol (p<0.001), HDL (p=0.001), LDL (p<0.001), VLDL (p<0.001), triglycerides (p<0.001), and BMI groups. Conversely, no significant relationship was observed between B12 values and TSH (p=0.430), fT3 (p=0.462), or fT4 (p = 0.279).
Conclusion: In conclusion, our findings indicate that BMI significantly influences the lipid profile of individuals; however, it does not exhibit a direct relationship with B12 levels or thyroid functions. Given the fact that obesity elevates cardiometabolic risks, particularly through heightened lipid levels, it is essential to monitor not only obese individuals but also those at risk for it as well, to reduce obesity and prevent its onset.

Keywords : BMI, obesity, vitamin B12, lipid, TSH, thyroid hormones

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Article available in :
Volume 6, Issue 1, 2025
Page : 50-56
https://doi.org/10.47582/jompac.1601700
Article Information
Received : 15 Ara 2024
Accepted : 29 Oca 2025
Published : 14 Şub 2025
Corresponding Author :

Vasfiye Demir Pervane: Department of Family Medicine, Faculty of Medicine, Dicle University, Diyarbakır, Turkiye

[email protected]
Citation : Demir Pervane V, Gökdemir Ö, Aygün O, Gündoğdu SC, Erten Bucaktepe PG, Çelepkolu T. The relationship between thyroid functions, vitamin B12, and lipid profiles across different BMI categories in adults. J Med Palliat Care. 2025;6(1):50-56.

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