JOMPAC
Journal of Medicine and Palliative Care

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

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Original Article
Clinical outcomes of topical epidermal growth factor in diabetic foot ulcers
Abstract
Aims: This study aims to evaluate the clinical outcomes of topical epidermal growth factor (EGF) in the treatment of diabetic foot ulcers (DFUs) in outpatient settings. It also seeks to provide guidance on the use of topical EGF, which is eligible for reimbursement for treating DFUs in our country.
Methods: A retrospective analysis involved 55 patients with DFUs who received topical EGF treatment. Patients received training on EGF application and were monitored for healing outcomes. Data were collected from medical records, including demographic information, wound characteristics, and laboratory results. Statistical analysis was performed using IBM SPSS version 25, employing chi-square, Pearson's correlation, and ANOVA tests to evaluate healing rates and associated factors.
Results: The study found that 70.9% of patients achieved complete wound closure within an average of 15.44 weeks. Healing rates were significantly higher for non-plantar wounds (83.8%) compared to plantar wounds (44.4%). Factors such as age, body weight, and body-mass index (BMI) were identified as influencing healing outcomes, with higher weights and BMI correlating with lower healing rates. Mild skin irritation was the only adverse effect reported.
Conclusion: Topical EGF demonstrates promising potential for enhancing the healing of DFUs in outpatient settings, achieving a healing rate comparable to specialized diabetic foot centers. The findings underscore the importance of considering patient-specific factors, such as obesity and adherence to treatment recommendations, to optimize healing outcomes. Further research with larger, multi-center studies is necessary to validate these results and improve access to effective treatments for patients with DFUs.

Keywords : Diabetic foot ulcers, epidermal growth factor, wound healing

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Article available in :
Volume 6, Issue 1, 2025
Page : 39-44
https://doi.org/10.47582/jompac.1600752
Article Information
Received : 13 Ara 2024
Accepted : 27 Oca 2025
Published : 14 Şub 2025
Corresponding Author :

Levent Demir: Department of Underwater and Hyperbaric Medicine, Kayseri City Training and Research Hospital, Kayseri, Turkiye

[email protected]
Citation : Demir L, Kahraman M, Altun İ, Avcı M, Kılıç S, Aslan S. Clinical outcomes of topical epidermal growth factor in diabetic foot ulcers. J Med Palliat Care. 2025;6(1):39-44.

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