JOMPAC
Journal of Medicine and Palliative Care

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

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Original Article
Measurement of mean platelet volume in the diagnosis of acute ischemic stroke and transient ischemic attack
Abstract
Aims: The primary aim of this study is to investigate the potential role of mean platelet volume (MPV) in the diagnostic and prognostic evaluation of acute ischemic stroke (AIS) and transient ischemic attack (TIA), focusing on its clinical significance and role in diagnostic processes. This study aims to evaluate the clinical significance of MPV in patients with AIS and TIA and its role in diagnostic processes.
Methods: This retrospective study was conducted between June 15 and December 15, 2014, at the Emergency Medicine Department of Haydarpaşa Numune Training and Research Hospital. The study included 300 patients diagnosed with AIS or TIA and 100 healthy individuals matched for demographic characteristics as the control group. Participants were evaluated based on vascular risk factors such as hypertension, diabetes, and hyperlipidemia, and AIS subgroups were analyzed according to the TOAST classification. MPV and platelet counts, along with biochemical parameters, were measured, and statistical analyses were performed utilizing SPSS software.
Results: MPV values in the case group were significantly higher compared to the control group (p<0.001). No significant differences were observed in platelet counts between the two groups (p>0.05). MPV demonstrated no significant associations with hypertension, hyperlipidemia, or other vascular risk factors; however, patients with a history of TIA exhibited higher MPV levels compared to those without, although the difference was not statistically significant. A weak but statistically significant negative correlation was identified between MPV and platelet counts (r=-0.20, p<0.05).
Conclusion: MPV demonstrates potential as a significant biomarker in the diagnostic and prognostic processes of AIS and TIA. Nevertheless, the inconsistencies observed in the literature regarding the relationship between MPV and risk factors necessitate more extensive, prospective, and standardized studies to elucidate its clinical utility. The evidence suggests that MPV may contribute to enhancing diagnostic accuracy in clinical practice.

Keywords : Acute ischemic stroke, transient ischemic attack, mean platelet volume, biomarker, cerebrovascular disease

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1. GBD 2021 Stroke Risk Factor Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2021: a systematic analysis for the Global burden of disease study 2021. Lancet Neurol. 2024;23(10):973-1003. doi:10.1016/S1474-4422(24)00369-7
2. Campbell BC, Khatri P. Stroke. Lancet. 2020;396(10244):129-142. doi:10. 1016/S0140-6736(20)31179-X
3. Easton JD, Saver JL, Albers GW, et al. Definition and evaluation of transient ischemic attack. Stroke. 2009;40(6):2276-2293. doi:10.1161/STROKEAHA.108.192218
4. Powers WJ, Rabinstein AA, Ackerson T, et al. 2018 Guidelines for the early management of patients with acute ischemic stroke. Stroke. 2018; 49(3):e46-e110. doi:10.1161/STR.0000000000000158
5. Bath PM, Butterworth RJ. Platelet size: measurement, physiology, and vascular disease. Blood Coagul Fibrinolysis. 1996;7(2):157-161. doi:10. 1097/00001721-199602000-00011
6. Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost. 2010;8(1):148-156. doi:10.1111/j.1538-7836.2009.03584.x
7. Greisenegger S, Endler G, Hsieh K, et al. Is elevated mean platelet volume associated with worse outcomes in patients with acute ischemic cerebrovascular events? Stroke. 2004;35(7):1688-1691. doi:10.1161/01.STR.0000130512.81212.a2
8. Shah B, Xie D, Mohler ER, Berger JS. Mean platelet volume and its association with coronary artery disease and diabetes mellitus: a systematic review and meta-analysis. J Thromb Thrombolysis. 2012;33(2): 157-164. doi:10.1007/s11239-011-0643-6
9. Tohgi H, Suzuki H, Tamura K, Saito Y. Platelet size in acute cerebral infarction. Stroke. 1991;22(6):748-751. doi:10.1161/01.STR.22.6.748
10. Giannini S, Falcone G, Sessa M, et al. Prognostic role of mean platelet volume in acute ischemic stroke: a systematic review and meta-analysis. Eur J Neurol. 2023;30(2):354-363. doi:10.1111/ene.15045
11. Feigin VL, Stark BA, Johnson CO, et al. Global, regional, and national burden of stroke, 1990-2019: a systematic analysis. Lancet Neurol. 2021; 20(10):795-820. doi:10.1016/S1474-4422(21)00252-0
12. Sharpe PC, Trinick TR. Mean platelet volume in diabetes mellitus. QJM. 1993;86(10):739-742. doi:10.1093/qjmed/86.10.739
13. Hekimsoy Z, Payzin B, Ornek T, Kandogan G. Mean platelet volume in type 2 diabetic patients. J Clin Pathol. 2004;57(9):930-933. doi:10.1136/jcp.2003.013777
14. McCabe DJ, Harrison P, Mackie IJ, et al. Platelet degranulation and monocyte-platelet complex formation in acute ischemic stroke. Stroke. 2004;35(3):764-769. doi:10.1161/01.STR.0000117574.19325.96
15. Butt AR, Sultan MA, Iqbal Z, et al. The role of platelets in the pathophysiology of atherosclerosis. Platelets. 2020;31(5):647-655. doi:10. 1080/09537104.2019.1709540
16. Papanas N, Symeonidis G, Maltezos E, et al. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets. 2004;15(8):475-478. doi: 10.1080/0953710042000273839
17. Brown AS, Hong Y, de Belder A, et al. Platelet size and reactivity in diabetes mellitus and coronary artery disease. Platelets. 1997;8(5):287-290. doi:10.1080/09537109776794
18. Nadar SK, Blann AD, Kamath S, et al. Platelet morphology in essential hypertension: cardiovascular risk relationships. J Hum Hypertens. 2004; 18(5):307-312. doi:10.1038/sj.jhh.1001671
19. Martin JF, Trowbridge EA, Salmon G, Plumb J. The physiological significance of platelet volume changes in health and disease. Blood. 1983;62(3):665-675. doi:10.1182/blood.V62.3.665.665
20. Endler G, Klimesch A, Sunder-Plassmann H, et al. Mean platelet volume and cardiovascular events. Clin Chem Lab Med. 2002;40(10):1058-1061. doi:10.1515/CCLM.2002.181
21. Briggs C, Kunka S, Hart D, et al. Mean platelet volume measurement: EDTA sample stability and timing. Clin Lab Haematol. 2004;26(5):377-379. doi:10.1111/j.0141-9854.2004.00513.x
22. Lippi G, Salvagno GL, Montagnana M, et al. Pre-analytical variability in mean platelet volume assessment. Clin Biochem. 2007;40(8):651-655. doi:10.1016/j.clinbiochem.2007.01.013
23. Butt AR, Sultan MA, Yaseen F. Anticoagulants and MPV variability. Platelets. 2019;30(7):891-900. doi:10.1080/09537104.2018.1556589
24. Bath PM, Butterworth RJ. Platelet size and vascular disease. Stroke. 1996;27(7):1325-1328. doi:10.1161/01.STR.27.7.1325
25. O&#39;Malley T, Langhorne P, Elton RA, Stewart C. Platelet size and density in stroke patients. Stroke. 1995;26(6):995-999. doi:10.1161/01.STR.26.6. 995
26. Bath PM, Woodhouse LJ, Scutt P, et al. Platelet reactivity in stroke patients. Lancet. 2000;355(9201):129-133. doi:10.1016/S0140-6736(99) 03318-1
27. Giannini S, Bivona A, Rosa C, et al. Mean platelet volume and clinical outcomes in cerebrovascular disease. Eur J Neurol. 2023;30(3):456-468. doi:10.1111/ene.15045
28. Feigin VL, Roth GA, Naghavi M, et al. Global burden of neurological disorders: 1990-2019. Lancet Neurol. 2022;21(9):789-802. doi:10.1016/S1474-4422(22)00235-1
29. Powers WJ, Derdeyn CP, Biller J, et al. Acute ischemic stroke guidelines update. Stroke. 2021;52(2):e1-e18. doi:10.1161/STR.0000000000000355
30. Butt AR, Sultan MA. Novel biomarkers in cerebrovascular events. Neurology. 2022;24(5):123-128. doi:10.1212/WNL.0000000000201234
31. Lippi G, Favaloro EJ. Standardization in mean platelet volume measurement. Clin Biochem. 2022;98:12-19. doi:10.1016/j.clinbiochem. 2022.02.004
32. Martin JF, Towbridge EA. Megakaryocyte ploidy and platelet variability. BMJ. 1983;287(6606):1565-1568. doi:10.1136/bmj.287.6606.1565
Article available in :
Volume 6, Issue 1, 2025
Page : 7-12
https://doi.org/10.47582/jompac.1590302
Article Information
Received : 23 Kas 2024
Accepted : 26 Ara 2024
Published : 14 Şub 2025
Corresponding Author :

Erkan Boğa: Department of Emergency Medicine, Esenyurt Necmi Kadıoğlu State Hospital, İstanbul, Turkiye

[email protected]
Citation : Boğa E. Measurement of mean platelet volume in the diagnosis of acute ischemic stroke and transient ischemic attack. J Med Palliat Care. 2025;6(1):7-12.

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