JOMPAC
Journal of Medicine and Palliative Care

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

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Original Article
Impaired left ventricular function in lean women with PCOS: insights from speckle tracking echocardiography
Abstract
Aims: We aimed to conduct a study examining left ventricular function (LVEF) in lean women PCOS patients with speckle tracking echocardiography.
Methods: The study included 60 patients diagnosed with PCOS and 30 healthy controls matched for age and body mass index. Morning fasting blood samples were collected to measure levels of glucose, insulin, high-sensitivity C-reactive protein (hs-CRP), and lipids. Left ventricular function (LVF) was evaluated using two-dimensional speckle tracking echocardiography (2D-STE) and real-time three-dimensional echocardiography (3D-Echo). Global strain was assessed from three standard apical views using 2D-STE.
Results: The hs-CRP levels in lean women with PCOS were significantly higher compared to the control group (2.34±1.07 vs. 1.13±0.54; p=0.01). The peak longitudinal strain values in the 2-chamber, 4-chamber, and long-axis views were lower in lean women with PCOS compared to the control group (15.9±1.2 vs. 19.4±1.2; p=0.01, 17.0±1.1 vs. 19.2±1.4; p=0.01, 16.3±1.3 vs. 19.2±1.5; respectively, p=0.01). According to the multiple regression model, global strain was independently associated with hs-CRP (ß=0.31, p=0.04), the ratio of early diastolic mitral inflow velocity (E) to early diastolic annular velocity (E/E’ ratio) (ß=0.33, p=0.01), and ejection fraction (EF) (ß=0.35, p=0.01).
Conclusion: Our findings reveal that lean women with PCOS exhibit significantly higher levels of high-sensitivity C-reactive protein (hs-CRP) compared to healthy controls. Furthermore, the peak longitudinal strain values across multiple cardiac views were notably lower in the PCOS group, suggesting impaired left ventricular function. These results highlight the importance of monitoring cardiovascular health in lean women with PCOS, as they are at an increased risk of developing left ventricular dysfunction despite their lean body mass index.

Keywords : PCOS, high-sensitivity C-reactive protein, echocardiography

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Article available in :
Volume 5, Issue 4, 2024
Page : 214-218
https://doi.org/10.47582/jompac.1515967
Article Information
Received : 14 Tem 2024
Accepted : 27 Ağu 2024
Published : 29 Ağu 2024
Corresponding Author :

Atilla Karateke: Department of Obstetrics and Gynecology, Reyhanlı MMT Amerikan Hospital, Hatay, Turkiye

[email protected]
Citation : Karateke A, Kurt M, Dokuyucu R.Impaired left ventricular function in lean women with PCOS: insights from speckle tracking echocardiography. J Med Palliat Care. 2024;5(4):214-218.

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