JOMPAC
Journal of Medicine and Palliative Care

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

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Original Article
The relationship between triglyceride/high-density lipoprotein cholesterol ratio and the functional significance of coronary lesions
Abstract
Aims: Have shown that triglycerides (TG) are an independent risk factor for cardiovascular disease (CVD). Dyslipidemia characterized by low high-density lipoprotein cholesterol (HDL-C) has been shown to be associated with symptoms of coronary artery disease (CAD). In studies, the TG/HDL-C ratio has been found to be strongly associated with parameters indicative of the severity of coronary disease. In this study, we aimed to investigate whether the TG/HDL-C ratio is associated with the functional significance of moderate coronary artery lesions.
Methods: A total of 102 consecutive patients, 72 male and 30 female, who underwent measurement of fractional flow reserve (FFR) due to moderate coronary stenosis (quantitative coronary analysis 40-70%) on angiography were included in the study. An FFR value ?0.80 was accepted for hemodynamic significance.
Results: Among the 102 patients included in the study, it was determined that 52 (50.9%) had significant functional stenosis. Left ventricular ejection fraction of Group II was lower than Group I (60 (55-62.5) vs. 55(50-60), p=0.006). The male patient ratio was higher in Group II, but the difference between the two groups was not significant (68% and 77%, respectively, p=0.072). Univariate and multivariate logistic regression analysis showed that TG/HDL-C (OR=1.278, 95% CI=1.078-1.514, p=0.005) was an independent determinant of significant functional stenosis. ROC analysis revealed that the TG/HDL-C value was 3.89 and provided 64% specificity and 61.5% sensitivity in predicting hemodynamically significant coronary artery stenosis.
Conclusion: Elevated TG/HDL-C values are associated with the functional significance of angiographically moderate coronary artery stenosis.

Keywords : Coronary artery disease, triglyceride, fractional flow reserve, HDL-C

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Article available in :
Volume 5, Issue 3, 2024
Page : 149-154
https://doi.org/10.47582/jompac.1469728
Article Information
Received : 17 Apr 2024
Accepted : 03 May 2024
Published : 28 Jun 2024
Corresponding Author :

Can Özkan: Department of Cardiology, Bursa City Hospital, Bursa, Turkiye

[email protected]
Citation : Can Özkan. The relationship between triglyceride/high-density lipoprotein cholesterol ratio and the functional significance of coronary lesions. J Med Palliat Care. 2024;5(3):149-154.

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