JOMPAC
Journal of Medicine and Palliative Care

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

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Original Article
Assessment of biomarkers indicating activation of the complement system in pregnant women with fetal growth restriction
Abstract
Aims: To compare serum levels of sC5b-9, C3, C4, C1-INH, and CH50, which are indicators of complement system activation and regulatory processes, in pregnant women with and without fetal growth restriction (FGR).
Methods: This study enrolled eighty-six women with gestational age between 24 and 36 weeks. Maternal blood samples were obtained from 43 patients diagnosed with FGR and 43 from healthy pregnancies. Serum complement levels were measured using commercially available ELISA kits according to the manufacturer’s instructions (SunRed, China).
Results: When the levels of complement activation biomarkers of pregnancies with FGR were compared with those of healthy pregnancies, the C1est level was significantly higher, C4 and CH50 levels were slightly lower, and Sc5b9 and C3 levels were similar.
Conclusion: While the exact role of complement activation in FGR remains fully elucidated, the elevated levels of C1-INH in women with FGR suggest a compensatory mechanism to mitigate thrombus formation and inflammation. This adaptive response may be a potential therapeutic target for improving placental function and pregnancy outcomes.

Keywords : Complement system, fetal growth restriction, pregnancy, placenta

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Article available in :
Volume 5, Issue 2, 2024
Page : 129-134
https://doi.org/10.47582/jompac.1466260
Article Information
Received : 07 Nis 2024
Accepted : 27 Nis 2024
Published : 30 Nis 2024
Corresponding Author :

Işıl Turan Bakırcı: Division of Perinatology, Department of Obstetrics and Gynecology, Başakşehir Çam and Sakura City Hospital, İstanbul, Turkey

[email protected]
Citation : Ersan F, Turan Bakırcı I, Şener G, Çallıoğlu N, Atalay S, Tuna G. Assessment of biomarkers indicating activation of the complement system in pregnant women with fetal growth restriction. J Med Palliat Care. 2024;5(2):129-134.

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