JOMPAC
Journal of Medicine and Palliative Care

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

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Original Article
Evaluation of metabolic parameters of microsatellites stable and instable colorectal cancer patients via PET/CT
Abstract
Aims: Microsatellite instability has been determined as an important indicator in selecting chemotherapy drugs in colorectal cancer. Within the scope of this research, we aimed to elucidate the pathology reports and determine whether the metabolic parameters detected by PET/CT differ in MSI-positive and negative patients.
Methods: A total of 35 patients were analyzed retrospectively. The patient population consisted of patients who applied to the Nuclear Medicine Department with a diagnosis of colon or rectum cancer, underwent PET/CT imaging for staging purposes, and were operated on.
Results: A total of 35 colon or rectum cancer patients were included in this retrospective analysis. When microsatellite instability was analyzed among the patients, it was found that female patients comprised 4 microsatellite instability-positive and 16 microsatellite instability-negative individuals. On the other hand, 5 of the males were microsatellite instability positive, and 10 were microsatellite instability negative. The mean SUVmax value was 16.4±8.2, SUVmean was 8.1±1.9, TLG was 392.4±520.8, and MTV was 26.5±25.4 in the microsatellite instability-positive individuals. On the other hand, the mean SUVmax value was 22.7±9.7, SUVmean was 5.2±2.2, TLG was 316.4±325.7, and MTV was 21.7±21.7 in the microsatellite instability-negative individuals.
Conclusion: With the advancement of image analysis technology, MTV, and TLG, volumetric indexes derived from 18F-FDG PET have been proposed for risk stratification of cancer patients. Regarding the outcomes of this research, the semiquantitative and metabolic parameters obtained by PET/CT are not different in colorectal cancer cases with instable and stable microsatellites.

Keywords : Colorectal cancer, microsatellite instability, positron emission tomography/computed tomography (PET/CT), mismatch repair genes (MMR), standardized uptake value (SUV)

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Article available in :
Volume 5, Issue 2, 2024
Page : 124-128
https://doi.org/10.47582/jompac.1462904
Article Information
Received : 01 Nis 2024
Accepted : 22 Nis 2024
Published : 30 Nis 2024
Corresponding Author :

Şadiye Altun Tuzcu: Department of Nuclear Medicine, Faculty of Medicine, Dicle University, Diyarbakır, Turkiye

[email protected]
Citation : Altun Tuzcu Ş, Çetin İB, Güzel F, Çetinkaya E, Taşdemir B, Büyükbayram H. Evaluation of metabolic parameters of microsatellites stable and instable colorectal cancer patients via PET/CT. J Med Palliat Care. 2024;5(2):124-128.

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