JOMPAC
Journal of Medicine and Palliative Care

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

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Original Article
Pan-immune inflammatory value a new diagnostic biomarker in postmenopausal osteoporosis
Abstract
Aims: Postmenopausal osteoporosis (PMOP) is one of the most common bone diseases. We aimed to investigate the relationship between pan-immune inflammatory value and decreased bone mineral density in postmenopausal women.
Methods: This prospective cross-sectional study was composed of 186 postmenopausal women. Osteoporosis was diagnosed with dual-energy X-ray absorptiometry (DEXA) results according to World Health Organization (WHO) recommendations and patients were separated into 3 groups; 1. control group with a T-score >-1; 2. group osteopenia with a T-score between -1.0 and -2.5; 3. group osteoporosis with a T-score ?-2.5. After the physical examinations of all patients, venous blood samples were collected and the pan-immune inflammation value (PIV) was calculated. The parameters were evaluated statistically with the PIV value between the groups.
Results: Groups are similar in terms of age, menopausal age, education, and occupation. PIV was significantly higher in postmenopausal women with osteoporosis than women with osteopenia and the control group (p<0.001, p<0.001). PIV was significantly higher in postmenopausal women with osteopenia than the control group (p<0.001). Distinguishing between osteoporosis and osteopenia, PIV ?306.20 was 72.6% sensitivity, 69.4% specificity, and 71.7% negative predictive value. Distinguishing between osteopenia and control, PIV ?152.02 was 85.5% sensitivity, 56.5% specificity, 66.3% positive predictive value, and 79.5% negative predictive value.
Conclusion: In our study, we found that the PIV was statistically higher in PMOP, it was also statistically higher in postmenopausal women with osteopenia compared to healthy controls. We believe that PIV can be a cheap, easy, and reliable evaluation parameter for determining the risk of osteoporosis and osteopenia in women with PMOP.

Keywords : Pan-immune-inflammatory value, postmenopausal osteoporosis, osteopenia

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Article available in :
Volume 5, Issue 2, 2024
Page : 105-111
https://doi.org/10.47582/jompac.1447017
Article Information
Received : 04 Mar 2024
Accepted : 19 Mar 2024
Published : 30 Nis 2024
Corresponding Author :

Pınar Özge Başaran: Department of Physical Medicine and Rehabilitation, Erol Olçok Training and Research Hospital, Hitit University, Çorum, Turkiye

[email protected]
Citation : Başaran PÖ, Tutan D. Pan-immune inflammatory value a new diagnostic biomarker in postmenopausal osteoporosis. J Med Palliat Care. 2024;5(2):105-111.

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