JOMPAC
Journal of Medicine and Palliative Care

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

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Original Article
Diagnostic performance of whole blood viscosity indices in predicting the presence and severity of coronary artery disease
Abstract
Aims: Growing evidence suggests that blood viscosity plays a crucial role in both the development and acceleration of atherosclerosis. In this study, aimed to investigate the diagnostic performance of the mean platelet volume-age-total protein-hematocrit (MAPH) score, a new index for blood viscosity, in predicting the presence and severity of CAD in patients with suspected coronary artery disease (CAD).
Methods: We retrospectively evaluated 431 patients who underwent coronary angiography. SYNTAX score (SS) were divided into 3 groups; low group (<22), intermediate group (22-32) and, high group (?32). Low (LSR) and and high (HSR) shear rates were derived using values of total protein and hematocrit. The MAPH score was calculated based on the threshold values of mean platelet volume, age, total protein, and hematocrit for predicting CAD.
Results: The median LSR (60.7 vs. 43.1, p<0.001), mean HSR (17.3±1.3 vs. 16.2±1.2, p<0.001), and mean MAPH score (2.7±0.8 vs. 1.6±0.5, p<0.001) were higher in the CAD group compared to the non-CAD group. These indices of blood viscosity were found to be higher in the intermediate-high SS group compared to the low SS group. The threshold value of MAPH score for predicting CAD was >2 (sensitivity=78.2%, specificity=70.0%). It also had a graduated threshold value (>3, sensitivity=71.1%, specificity=62.5%) in distinguishing intermediate-high SS than low SS groups. In predicting both the presence and severity of CAD, the MAPH score exhibited superior diagnostic performance relative to the levels of LSR and HSR.
Conclusion: In patients with suspected CAD, a gradual increase in the MAPH score demonstrated significant diagnostic performance in distinguishing both the presence and severity of CAD. In these patients, the MAPH score may serve as a potential screening tool and can be utilized for risk stratification.

Keywords : Blood viscosity, coronary artery disease, MAPH score, microcirculation, SYNTAX score

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Article available in :
Volume 5, Issue 1, 2024
Page : 48-56
https://doi.org/10.47582/jompac.1424294
Article Information
Received : 23 Oca 2024
Accepted : 17 Şub 2024
Published : 29 Şub 2024
Corresponding Author :

Ahmet Kıvrak: Department of Cardiology, Ankara Etlik City Hospital, Ankara, Turkiye

[email protected]
Citation : Kıvrak A, Yıldırım A. Diagnostic performance of whole blood viscosity indices in predicting the presence and severity of coronary artery disease. J Med Palliat Care. 2024;5(1):48-56.

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