JOMPAC
Journal of Medicine and Palliative Care

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

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Original Article
Comparison of three different doses of cis-atracurium under isoflurane anesthesia
Abstract
Aims: In this study; we compared the effects of three different doses of cis-atracurium, a nondepolarizing muscle relaxant agent, on neuromuscular blockade duration, endotracheal intubation quality and hemodynamic parameters under isoflurane anaesthesia. Methods: A total of 60 patients (ASA I-II) were included in the study. Patients were premedicated with 10 mg diazepam intramuscularly 45 minutes before the operation. After the patients were transferred to the operating room, they were monitored noninvasively for heart rate and arterial blood pressure. Train of Four (TOF)-GUARD acceleration monitor was used for neuromuscular evaluation. All patients were administered 1 mg/kg fentanyl and 2 mg/kg propofol at induction, and anaesthesia maintenance was provided with 1.5% isoflurane+50% N2O+50% O2. The patients were divided into three groups according to the dose of cisatracurium administered: 0.15 mg/kg was administered to Group 1, 0.20 mg/kg was administered to Group 2, and 0.40 mg/kg cis-atracurium was administered to Group 3. Endotracheal intubation was performed at 120 seconds, and the block time of 99-100% (effect onset time) was recorded. Result: Although the endotracheal intubation quality was evaluated as excellent and/or good in all three groups, the intubation quality of Group 3 was statistically higher than the other two groups (p<0.05). In hemodynamic measurements, no significant difference was observed within and between groups in all three groups. While the onset of effect was significantly shorter in the third group compared to the other two groups, the clinical effect duration was more prolonged. No significant difference was observed between all three groups regarding the postoperative recovery period and quality. Conclusion: The 0.4 mg/kg application dose of cis-atracurium is superior to other recommended dose groups due to its high intubation quality, short onset of action, not causing any severe hemodynamic changes or side effects, and good recovery quality and duration.

Keywords : Cis-atracurium, neuromuscular block quality, general anaesthesia, nondepolarizing muscle relaxant

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Article available in :
Volume 5, Issue 1, 2024
Page : 29-35
https://doi.org/10.47582/jompac.1419484
Article Information
Received : 14 Oca 2024
Accepted : 07 Şub 2024
Published : 29 Şub 2024
Corresponding Author :

Ümit Murat Parpucu: Department of Anesthesiology and Reanimation, Gulhane Faculty of Health Sciences, University of Health Sciences, Ankara, Turkey

[email protected]
Citation : Parpucu ÜM. Comparison of three different doses of cis-atracurium under isoflurane anesthesia. J Med Palliat Care. 2024;5(1):29-35.

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