JOMPAC
Journal of Medicine and Palliative Care

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

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Original Article
Does the prevalence of subclinical coronary atherosclerosis increase in primary hyperparathyroidism; coronary flow reserve and plasma aterogenic index in patients with primary hyperparathyroidism?
Abstract
Aims: The coronary flow reserve (CFR) is a sign of early-stage coronary artery disease (CAD). Plasma atherogenic index (PAI) is related to atherosclerosis and cardiovascular mortality. Therefore, our aim was to determine CFR and PAI in patients with primary hyperparathyroidism (PHPT) and investigate whether PAI can be used in the detection of early-stage CAD.
Methods: The sample was comprised of 44 patients with PTHT and 33 healthy volunteers. We defined CFR as the ratio of the hyperemic diastolic peak velocity to the baseline diastolic peak velocity. PAI values were calculated with the formula of log 10 triglyceride (TRG)/high-density lipoprotein (HDL).
Results: The comparison of the groups for PAI and CFR demonstrated that PAI levels were significantly higher while CFR levels were significantly lower in the PTHT patients (p<0.01, p=0.01, respectively). The correlation analysis revealed that CFR was negatively correlated with PAI and TRG (PAI- p<0.0001 r=-0.537). The multivariate logistic regression analysis showed that only a high PAI level (OR: 151.6, 95% confidence interval (CI): 4.1-5480, p=0.006) was an independent predictor of reduction in CFR in PHPT patients.
Conclusion: Overall, we found an independent correlation between PAI and CFR values. Hence, PAI may be useful in identifying PHPT patients facing a high risk of adverse cardiovascular events and may also allow early diagnosis of subclinical atherosclerosis.

Keywords : Primary hyperparathyroidism, plasma atherogenic index, atherosclerosis, coronary flow reserve

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Article available in :
Volume 5, Issue 1, 2024
Page : 1-8
https://doi.org/10.47582/jompac.1403076
Article Information
Submitted : 11 Ara 2023
Accepted : 18 Oca 2024
Corresponding Author :

Eyüp Özkan: Department of Cardiology, Başakşehir Çam & Sakura City Hospital, İstanbul, Turkey

[email protected]
Citation : Özkan E, Genç Ö, Yılmaz Y, Şimşek Y. Does the prevalence of subclinical coronary atherosclerosis increase in primary hyperparathyroidism; coronary flow reserve and plasma aterogenic index in patients with primary hyperparathyroidism? J Med Palliat Care. 2024;5(1):1-8.

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