JOMPAC

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

EndNote Style
Index
Review
Hemorheology in thyroid abnormalities: old team player, new insights
Thyroid dysfunctions significantly impact various physiological processes, extending their influence on hemorheological properties and microcirculation. This comprehensive review explores the intricate relationship between thyroid disorders and hemorheology, emphasizing the substantial effects on blood flow dynamics and tissue perfusion. Examining the alterations in blood viscosity, erythrocyte behavior, and microvascular circulation in both hypothyroidism and hyperthyroidism reveals crucial insights into the pathophysiology of these conditions. Furthermore, elucidating the hemorheological changes associated with thyroid dysfunctions offers potential avenues for improved clinical management strategies. This review synthesizes current research findings, highlighting the importance of considering hemorheological aspects in understanding the complexities of thyroid-related complications and advancing patient care paradigms.


1. Katznelson L, Atkinson J, Cook D, Ezzat S, Hamrahian A, MillerK. AACE Guidelines. Endocr Pract. 2011;17(4):1-44.
2. Kravets I. Hyperthyroidism: diagnosis and treatment. Am FamPhysician. 2016;93(5):363-370.
3. Bahn RS, Burch HB, Cooper DS, et al. Hyperthyroidism andother causes of thyrotoxicosis: management guidelines of theAmerican Thyroid Association and American Association ofClinical Endocrinologists. Thyroid. 2011;21(6):593-646.
4. Sari O, Tanoglu A, Aydogan U, et al. Serum visfatin levels beforeand after levothyroxin treatment in cases with hypothyroidismand subclinical hypothyroidism and their relationships betweenthe lipid levels. Biomed Res. 2012;23(1):55-59.
5. Cho Y Il, Cho DJ. Hemorheology and microvascular disorders.Korean Circ J. 2011;41(6):287-295.
6. Popel AS, Johnson PC. Microcirculation and hemorheology. Platelets.2005;37:43-69. doi.org/10.1146/annurev.fluid.37.042604.133933
7. Kawa MP, Grymula K, Paczkowska E, et al. Clinical relevance ofthyroid dysfunction in human haematopoiesis: biochemical andmolecular studies. Eur J Endocrinol. 2010;162(2):295-305.
8. Baskurt OK, Meiselman HJ. Blood rheology and hemodynamics.Semin Thromb Hemost. 2003;29(5):435-450.
9. Somer T, Meiselman HJ. Disorders of blood viscosity. Ann Med.1993;25(1):31-39.
10. Renoux C, Faivre M, Bessaa A, et al. Impact of surface-area-to-volume ratio, internal viscosity and membrane viscoelasticity onred blood cell deformability measured in isotonic condition. SciRep. 2019;9(1):1-7.
11. Chasis JA, Mohandas N. Erythrocyte membrane deformabilityand stability: two distinct membrane properties that areindependently regulated by skeletal protein associations. J CellBiol. 1986;103(2):343-350.
12. Kim J, Lee H, Shin S. Advances in the measurement of red bloodcell deformability: a brief review. J Cell Biotechnol. 2015;1(1):63-79.
13. Tomaiuolo G. Biomechanical properties of red blood cells inhealth and disease towards microfluidics. Biomicrofluidics.2014;8(5):1-19. doi.org/10.1063/1.4895755
14. Baskurt OK, Meiselman HJ. Erythrocyte aggregation: basicaspects and clinical importance. Clin Hemorheol Microcirc.2013;53(1-2):23-37.
15. Connes P, Dufour S, Pichon A, Favret F. Blood Rheology, BloodFlow, and Human Health. In: Bagchi D, Nair S, Sen CK, eds.Nutrition and Enhanced Sports Performance: Muscle Building,Endurance, and Strength. 2nd Edition. Elsevier Inc.: 2018: 359-369. doi.org/10.1016/B978-0-12-813922-6.00030-8
16. Baskurt OK, Meiselman HJ. Red blood cell “aggregability.” ClinHemorheol Microcirc. 2009;43(4):353-354.
17. Neu B, Meiselman HJ. Depletion-mediated red blood cellaggregation in polymer solutions. Biophys J. 2002;83(5):2482-2490.
18. Flormann DAD. Physical charaterization of red blood cellaggregation (Doctoral dissertation, Universität des Saarlandes).2017.
19. Baskurt OK, Boynard M, Cokelet GC, et al. New guidelinesfor hemorheological laboratory techniques. Clin HemorheolMicrocirc. 2009;42(2):75-97.
20. Panagoulis C, Halapas A, Chariatis E, Driva P, Matsakas E.Hyperthyroidism and the heart. Hell J Cardiol. 2008;49(3):169-175.
21. Mejia Osuna P, Udovcic M, Sharma MD. Hyperthyroidism andthe heart. Methodist Debakey Cardiovasc J. 2017;13(2):60-63.
22. Elblbesy MA, Shawki MM. Dependency of whole blood viscosityand plasma viscosity on electrolytes and lipids-an in vitro study.Int J Basic Appl Sci IJBAS-IJENS. 2016;16(03):168003-9494.
23. Dörr M, Robinson DM, Wallaschofski H, et al. Brief report: lowserum thyrotropin is associated with high plasma fibrinogen. JClin Endocrinol Metab. 2006;91(2):530-534.
24. Shih CH, Chen SL, Yen CC, et al. Thyroid hormone receptor-dependent transcriptional regulation of fibrinogen andcoagulation proteins. Endocrinol. 2004;145(6):2804-2814.
25. Erol-Yilmaz A, Atasever B, Mathura K, et al. Cardiacresynchronization improves microcirculation. J Card Fail.2007;13(2):95-99.
26. Elbers PWG, Prins WB, Plokker HWM, Van Dongen EPA, VanIterson M, Ince C. Electrical cardioversion for atrial fibrillationimproves microvascular flow independent of blood pressurechanges. J Cardiothorac Vasc Anesth. 2012;26(5):799-803. doi.org/10.1053/j.jvca.2012.04.016
27. Vayá A, Giménez C, Sarnago A, et al. Subclinical hypothyroidismand cardiovascular risk. Clin Hemorheol Microcirc. 2014;58(1):1-7.
28. Dintenfass L, Forbes CD, McDougall IR. Blood viscosity inhyperthyroid and hypothyroid patients. Pathophysiol HaemostThromb. 1974;3(5-6):348-352.
29. Franchini M. Hemostasis and thyroid diseases revisited. JEndocrinol Invest. 2004;27(9):886-892.
30. Akin MA, Aydogan S, Gunes T, Artis AS, Karakukcu M,Kurtoglu S. Changes of red blood cell rheology in newborns withcongenital hypothyroidism during treatment. J Matern NeonatalMed. 2013;26(15):1532-1536.
Volume 4, Issue 6, 2023
Page : 705-709
_Footer