JOMPAC
Journal of Medicine and Palliative Care

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

eISSN: 2717-7505
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Submit Manuscript

Index
Original Article
The role of the systemic inflammatory response index (SIRI) in the prediction of chronic total occlusion: useful or not?
Abstract
Aims: Inflammation is very important in the pathogenesis of atherosclerosis and coronary artery disease (CAD). Chronic total occlusion (CTO) is a chronic form of CAD and is common in patients with severe CAD. The aim of this study was to determine the association of the systemic inflammatory response index (SIRI), a marker of inflammation, with CTO.
Methods: Our study was retrospective and included 100 CAD patients with CTO and 100 CAD patients without CTO. SIRI was compared between the two groups.
Results: Among the basic clinical and laboratory characteristics of the patients, age, white blood cell, and neutrophil counts were statistically higher in the CTO group (p=0.044, p=0.044, p=0.036, respectively). SIRI parameters were similar between the groups, and no statistical difference was observed (p=0.111). According to the ROC analysis, the optimum cut-off value for SIRI was >1040 (sensitivity 70.0% and specificity 44.0%).
Conclusion: SIRI is not a useful predictor for the detection of CTO.

Keywords : Systemic inflammatory response index, chronic total occlusion, coronary artery disease

Download Article


1. Dagenais GR, Leong DP, Rangarajan S, et al. Variations incommon diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE): aprospective cohort study. Lancet. 2020;395(10226):785-794.
2. Sianos G, Werner GS, Galassi AR, et al. Recanalisation of chronictotal coronary occlusions: 2012 consensus document from theEuroCTO club. EuroIntervention. 2012;8(1):139-145.
3. Kahn JK. Angiographic suitability for catheter revascularizationof total coronary occlusions in patients from a communityhospital setting. Am Heart J. 1993;126(3 Pt 1):561-564.
4. Christofferson RD, Lehmann KG, Martin GV, Every N, CaldwellJH, Kapadia SR. Effect of chronic total coronary occlusion ontreatment strategy. Am J Cardiol. 2005;95(9):1088-1091.
5. Lawton JS, Tamis-Holland JE, Bangalore S, et al. 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: AReport of the American College of Cardiology/American HeartAssociation Joint Committee on Clinical Practice Guidelines.Circulation. 2022;145(3):e18-e114.
6. Gebhard C, Toma A, Min Z, et al. Preprocedural leucocyte countpredicts risk in patients with coronary chronic total occlusion.Thromb Haemost. 2017;117(11):2105-2115.
7. Li S, Chen H, Zhou L, Cui H, Liang S, Li H. Neutrophil-to-lymphocyte ratio predicts coronary artery lesion severity andlong-term cardiovascular mortality in patients with unstableangina pectoris. Acta Cardiol. 2022;77(8):708-715.
8. Isik T, Uyarel H, Tanboga IH, et al. Relation of red cell distributionwidth with the presence, severity, and complexity of coronaryartery disease. Coron Artery Dis. 2012;23(1):51-56.
9. Eyyupkoca F, Kocak A, Yildirim O, et al. Systemic immune-inflammation index predicted presence and severity of coronaryartery disease. Ann Med Res. 2022;29(8):794-801.
10. Dziedzic EA, Gasior JS, Tuzimek A, et al. Investigation ofthe associations of novel inflammatory biomarkers-systemicinflammatory index (SII) and systemic inflammatoryresponse index (SIRI)-with the severity of coronary arterydisease and acute coronary syndrome occurrence. Int J MolSci. 2022;23(17):9553.
11. Boyaci F, Akçay M, Gökdeniz T. Neutrophil/lymphocyte ratio andplatelet/lymphocyte ratio in predicting chronic total occlusion inST-segment elevation myocardial infarction. Harran ÜniversitesiTıp Fakültesi Derg. 2022;19(2):277-283.
12. Açıkgöz SK, Akboğa MK, Açıkgöz E, Yayla Ç, Şensoy B, AydoğduS. Red cell distribution width predicts totally occluded infarct-related artery in NSTEMI. Scand Cardiovasc J. 2016;50(4):224-229.
13. Yarlioglues M, Kurtul A. Association of red cell distribution widthwith noninfarct-related artery-chronic total occlusion in acutemyocardial infarction patients. Biomark Med. 2017;11(3):255-263.
14. Demir M, Özbek M. A novel predictor in patients with coronarychronic total occlusion: systemic immune-inflammation index:a single-center cross-sectional study. Rev Assoc Med Bras (1992).2022;68(5):579-585.
15. Hansson GK. Inflammation, atherosclerosis, and coronary arterydisease. N Engl J Med. 2005;352(16):1685-1695.
16. Tani S, Matsumoto M, Anazawa T, et al. Development of a modelfor prediction of coronary atherosclerotic regression: evaluationof high-density lipoprotein cholesterol level and peripheral bloodmonocyte count. Heart Vessels. 2012;27(2):143-150.
17. Yuan Y, Li P, Ye J. Lipid homeostasis and the formation ofmacrophage-derived foam cells in atherosclerosis. Protein Cell.2012;3(3):173-181.
18. Tamhane UU, Aneja S, Montgomery D, Rogers EK, EagleKA, Gurm HS. Association between admission neutrophil tolymphocyte ratio and outcomes in patients with acute coronarysyndrome. Am J Cardiol. 2008;102(6):653-657.
19. Huang G, Zhong XN, Zhong B, et al. Significance of white bloodcell count and its subtypes in patients with acute coronarysyndrome. Eur J Clin Invest. 2009;39(5):348-358.
20. Major AS, Fazio S, Linton MF. B-lymphocyte deficiency increasesatherosclerosis in LDL receptor-null mice. Arterioscler ThrombVasc Biol. 2002;22(11):1892-1898.
21. Ducloux D, Challier B, Saas P, Tiberghien P, Chalopin JM.CD4 cell lymphopenia and atherosclerosis in renal transplantrecipients. J Am Soc Nephrol. 2003;14(3):767-772.
22. Qi Q, Zhuang L, Shen Y, et al. A novel systemic inflammationresponse index (SIRI) for predicting the survival of patients withpancreatic cancer after chemotherapy. Cancer. 2016;122(14):2158-2167.
23. Urbanowicz T, Michalak M, Komosa A, et al. Predictive valueof systemic inflammatory response index (SIRI) for complexcoronary artery disease occurrence in patients presentingwith angina equivalent symptoms. Cardiol J. 2023;10.5603/CJ.a2023.0033.
24. Candemir M, Kiziltunç E, Nurkoç S, Şahinarslan A. Relationshipbetween systemic immune-inflammation index (SII) and theseverity of stable coronary artery disease. Angiology. 2021;72(6):575-581.
25. Liu Y, Ye T, Chen L, et al. Systemic immune-inflammationindex predicts the severity of coronary stenosis in patients withcoronary heart disease. Coron Artery Dis. 2021;32(8):715-720.
26. Şahin İ, Karabulut A, Kaya A, et al. Increased level of red celldistribution width is associated with poor coronary collateralcirculation in patients with stable coronary artery disease. TurkKardiyol Dern Ars. 2015;43(2):123-130.
27. Dash D. Coronary chronic total occlusion intervention: Apathophysiological perspective. Indian Heart J. 2018;70(4):548-555.
28. Bassuk SS, Rifai N, Ridker PM. High-sensitivity C-reactiveprotein: clinical importance. Curr Probl Cardiol. 2004;29(8):439-493.
Article available in :
Volume 4, Issue 5, 2023
Page : 542-546
https://doi.org/10.47582/jompac.1349803
Article Information
Received : 25 Ağu 2023
Accepted : 07 Eki 2023
Published : 27 Eki 2023
Corresponding Author :

Gökhan Ergün: Department of Cardiology, Kayseri City Training and Research Hospital, Kayseri

[email protected]
Citation : Ergün G, Doğan Y. The role of the systemic inflammatory response index (SIRI) in the prediction of chronic total occlusion: useful or not?. J Med Palliat Care. 2023;4(5):542-546.

Read: 33
Cited: 0
Download : 80
_Footer