JOMPAC
Journal of Medicine and Palliative Care

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

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Original Article
Systemic immune inflammation indices: novel predictors for preterm premature rupture of membranes and associated complications
Abstract
Aims: This study aimed to investigate the relationship between systemic immune inflammation (SII) and response indices (SIRI), which are new markers of systemic inflammation derived from immune cells, and preterm premature rupture of membranes (PPROM), as well as adverse pregnancy outcomes.
Methods: The retrospective study included 75 women with singleton pregnancies complicated by PPROM between the 24th and 34th gestational week and 75 healthy pregnant women who delivered at term without any additional diseases (control group). Inflammation indices were calculated based on neutrophil (N), platelet (P), lymphocyte (L), and monocyte (M) counts as follows: The neutrophil-to-lymphocyte ratio (NLR)=N/L; the platelet-to-lymphocyte ratio (PLR)=P/L; SII=(N×P)/L; and SIRI=(N×M)/L.
Results: The median NLR (4.8 vs. 3.5, p <0.001), median PLR (145.1 vs. 126.5, p<0.001), median SII (1208.6 vs. 807.4, p<0.001), and median SIRI (3.1 vs. 2.0, p<0.001) were higher in the PPROM group compared to the control group. Multiple logistic regression analysis showed that increased SIRI (OR= 7.05, p=0.010), as well as increased C-reactive protein levels were determined as independent predictors of PPROM. In the PPROM group, the SIRI was higher in the presence of combined complications compared to without complications (3.4 vs. 2.5, p<0.001). The SIRI showed superior diagnostic performance in predicting the presence and complications of PPROM compared to other inflammation indices.
Conclusion: The PPROM group had higher leukocyte-based inflammation indices compared to the control group. Due to the superior diagnostic performance of the SIRI in distinguishing both PPROM and combined complications compared to other leukocyte-based inflammation indices, it may serve as a significant screening tool for PPROM.

Keywords : Preterm premature rupture of membranes, immune inflammation index, pregnancy complications, neonatal outcomes

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Article available in :
Volume 4, Issue 5, 2023
Page : 516-523
https://doi.org/10.47582/jompac.1348845
Article Information
Received : 23 Ağu 2023
Accepted : 29 Eyl 2023
Published : 27 Eki 2023
Corresponding Author :

Gökçe Naz Küçükbaş: Department of Obstetrics and Gynecology, Kocaeli City Hospital, Kocaeli, Turkey

[email protected]
Citation : Küçükbaş GN, Yavuz A. Systemic immune inflammation indices: novel predictors for preterm premature rupture of membranes and associated complications. J Med Palliat Care. 2023;4(5):516-523.

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