JOMPAC
Journal of Medicine and Palliative Care

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

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Original Article
Prospective examination of Tp-e interval and Tp-e/QT ratio in breast cancer patients receiving radiation therapy
Abstract
Aims: The aim of this prospective study was to investigate ventricular repolarization using the Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio in breast cancer patients treated with adjuvant radiotherapy(RT) following systemic chemotherapy.
Methods: The study was designed as a national, single-center prospective study. According to the treatment protocol, electrocardiograms (ECGs) were taken from all patients on their first and last days of RT. Tp-e intervals, Tp-e/QT ratios, and Tp-e/QTc ratios were calculated based on the ECG recordings. The heart doses due to radiation exposure were examined with mean heart dose, V5, V10,V20, and V30 values.
Results: 51 postsurgical patients, who were all treated with AC followed by weekly paclitaxel and had an indication for adjuvant RT, were included in the study. The mean heart dose was observed as median 205 cGy, and the V30 value was 0.01%. When ECG measurements were analyzed, statistically significant increases were observed in Tp-e interval (p<0.001), QT interval (p=0.007), Tp-e/QT ratio (p<0.001), and Tp-e/QTc ratio (p<0.001) at the end of RT. Additionally, positive correlations were observed between mean heart dose and post RT Tp-e (r= 0.770,p<0.01) and Tp-e/QTc ratio (r = 0.778,p<0.01)
Conclusion: When compared to before RT, statistically significant prolongation of Tp-e interval and QT interval and increases in Tp-e/QT ratio and Tp-e/QTc ratio were detected which are thought to be predictive for ventricular repolarization process and ventricular rhythm disorders. In addition, the mean heart dose was positively correlated with Tp-e interval and Tp-e/QTc ratio.

Keywords : Radiotherapy, cardiac toxicity, breast cancer, Tp-e interval, Tp-e/QT ratio, Tp-e/QTc ratio

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Article available in :
Volume 4, Issue 4, 2023
Page : 362-367
https://doi.org/10.47582/jompac.1302914
Article Information
Received : 30 May 2023
Accepted : 30 Ağu 2023
Published : 30 Ağu 2023
Corresponding Author :

Necla Gürdal: Department of Radiation Oncology, Prof. Dr. Cemil Tascıoğlu City Hospital, İstanbul, Turkey

[email protected]
Citation : Gürdal N, Coşgun G, Dönmez Yılmaz B, Gürdal A. Prospective examination of Tp-e interval and Tp-e/QT ratio in breast cancer patients receiving radiation therapy. J Med Palliat Care. 2023;4(4):362-367.

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