JOMPAC
Journal of Medicine and Palliative Care

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

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Original Article
Evaluation of the association of anti-thyroid peroxidase with antinuclear antibodies and different antinuclear antibodies patterns
Abstract
Aims: To investigate the relationship between anti-thyroid peroxidase (TPO), a marker for Hashimoto’s thyroiditis, and antinuclear antibodies (ANA) and ANA patterns, biomarkers for systemic autoimmune diseases.
Methods: In this study, ANA and anti-TPO test results, obtained in our hospital laboratory between 2019 and 2022, were retrospectively evaluated. ANA was detected by the indirect immunofluorescence antibody method using commercial HEp-20-10 cell substrates and anti-TPO was determined by the sandwich immunoassay method using a commercial immunoassay analyzer.
Results: A total of 1750 patients’ results were analyzed. ANA was positive in 28.7% of anti-TPO-positive patients and 19% of anti-TPO-negative patients. While 6.4% (112/1750) of patients were positive for both ANA and anti-TPO, both test results were negative in 62.85% of patients (p<0.001). When the ANA patterns’ distribution in patients with ANA and anti-TPO positivity examined together, the homogeneous pattern was statistically significantly higher than the other patterns (p=0.043).
Conclusion: Individuals with autoimmune thyroid disease had a higher rate of autoantibodies not only to thyroid-specific antigens but also to non-thyroid-specific antigens. Further studies are needed on how epigenetic changes, such as histone modifications might cause other autoimmune diseases and increase their frequency.

Keywords : Autoimmunity, antinuclear antibodies, autoimmune disease, thyroid diseases, Hashimoto disease

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1. Hern&aacute;ndez-Negr&iacute;n H, Roque-Dapresa Y, Mart&iacute;nez-Morales O,Mederos-Portal A. Using multiple cause-of-death analysis toestimate systemic autoimmune disease mortality burden in low-and middle-income countries. MEDICC Review. 2021;23(2):69-74.
2. Frederick WM, Lars A, Karen HC, et al. Epidemiology ofenvironmental exposures and human autoimmune diseases:Findings from a National Institute of Environmental HealthSciences Expert Panel Workshop. J Autoimmun. 2012;39(4):259-271
3. Tsokos GC. Systemic lupus erythematosus. N Engl J Med.2011;365(22):2110-2121. doi:10.1056/NEJMra1100359
4. Andrade LEC, Damoiseaux J, Vergani D, Fritzler MJ. Antinuclearantibodies (ANA) as a criterion for classification and diagnosisof systemic autoimmune diseases. J Transl Autoimmun.2022;5:100145. doi:10.1016/j.jtauto.2022.100145
5. Bilgin M, Keskin A, Aci R, Baklacioglu HS, Arslanbek Erdem M.Darkness hormone or daylight hormone in women with systemiclupus erythematosus? Clin Rheumatol. 2023;42(1):93-99.
6. Conrad K, Bachmann M. Autoantibodies and systemicautoimmune diseases. Autoantibodies and Autoimmunity,2006;225-245.
7. Weetman A, DeGroot LJ. Autoimmunity to the Thyroid Gland.In: Feingold KR, Anawalt B, Blackman MR, et al (ed). Endotext(Internet). Jan 14. South Dartmouth (MA): MDText.com, Inc.;2000-. PMID: 25905407.
8. Siriwardhane T, Krishna K, Ranganathan V, et al. ExploringSystemic Autoimmunity in Thyroid Disease Subjects. J ImmunolRes. 2018;6895146.
9. Matusiewicz A, Str&oacute;zynska-Byrska J, Olesinska M.Polyautoimmunity in rheumatological conditions. Int J RheumDis. 2019;22(3):386-391.
10. Giuffrida G, Bagnato G, Campenn&igrave; A, et al. Non-specific rheumaticmanifestations in patients with Hashimoto&rsquo;s thyroiditis: a pilotcross-sectional study. J Endocrinolo Investigation. 2020;43(1):87-94.
11. Damoiseaux J, Andrade LEC, Carballo OG, et al. Clinicalrelevance of HEp-2 indirect immunofluorescent patterns: theinternational consensus on ANA patterns (ICAP) perspective.Ann Rheum Dis. 2019;78(7):879-889.
12. Moroni L, Bianchi I, Lleo A. Geoepidemiology, gender andautoimmune disease. Autoimmun Rev. 2012;11(6-7):A386-A392.
13. Agmon-Levin N, Damoiseaux J, Kallenberg C, et al. Internationalrecommendations for the assessment of autoantibodies to cellularantigens referred to as anti-nuclear antibodies. Ann Rheum Dis2014;73:17-23.
14. Tektonidou MG, Anapliotou M, Vlachoyiannopoulos P,Moutsopoulos HM. Presence of systemic autoimmune disordersin patients with autoimmune thyroid diseases. Ann Rheum Dis.2004;63(9):1159-1161.
15. Laz&uacute;rov&aacute; I, Benhatchi K, Rovensk&yacute; J, et al. Autoimmune thyroiddisease and autoimmune rheumatic disorders: A two-sidedanalysis. Ann New York Acad Sci. 2009;1173(1):211-216.
16. Morita S, Arima T, Matsuda M. Prevalence of nonthyroid specificautoantibodies in autoimmune thyroid diseases. J Clin EndocrinolMetab. 1995;80(4):1203-1206.
17. Solomon DH, Kavanaugh AJ, Schur PH. American Collegeof Rheumatology Ad Hoc Committee on ImmunologicTesting Guidelines. Evidence-based guidelines for the use ofimmunologic tests: antinuclear antibody testing. Arthritis Rheum.2002;47(4):434-444.
18. Carbone T, Pafundi V, Tramontano G, et al. Prevalence andserological profile of anti-DFS70 positive subjects from a routineANA cohort. Sci Rep. 2019;18;9(1):2177.
19. Wang B, Shao X, Song R, Xu D, Zhang JA. The emerging roleof epigenetics in autoimmune thyroid diseases. Front Immunol.2017;7;8:396.
20. Yan N, Zhou JZ, Zhang JA, et al. Histone hypoacetylation andincreased histone deacetylases in peripheral blood mononuclearcells from patients with Graves&rsquo; disease. Mol Cell Endocrinol.2015;15;414:143-147.
21. Angiolilli C, Kabala PA, Grabiec AM, et al. Histone deacetylase3 regulates the inflammatory gene expression programme ofrheumatoid arthritis fibroblast-like synoviocytes. Ann RheumDis. 2017;76(1):277-285.
22. Cheng F, Lienlaf M, Wang HW, et al. A Novel role for histonedeacetylase 6 in the regulation of the tolerogenic STAT3/IL-10pathway in APCs. J Immunol. 2014;15;193(6):2850-2862.
Article available in :
Volume 4, Issue 4, 2023
Page : 311-314
https://doi.org/10.47582/jompac.1317134
Article Information
Received : 20 Haz 2023
Accepted : 13 Ağu 2023
Published : 30 Ağu 2023
Corresponding Author :

Alper Togay: Department of Medical Microbiology, Tepecik Training and Research Hospital, University of Health Sciences, İzmir, Turkey

[email protected]
Citation : Togay A, İşbilen Başok B, Çolak A, Yılmaz N. Evaluation of the association of anti-thyroid peroxidase with antinuclear antibodies and different antinuclear antibodies patterns. J Med Palliat Care. 2023;4(4):311-314.

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