JOMPAC
Journal of Medicine and Palliative Care

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

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Original Article
The importance of serum estrone level in cases of chronic venous insufficiency in the lower extremity
Abstract
Aims: Chronic venous insufficiency (CVI) is a condition characterized by abnormal venous flow dynamics in the lower limbs and is associated with various risk factors such as pregnancy, age, obesity, and high estrogen states. One of these estrogens, estrone, is known to have cardioprotective effects. The study aimed to evaluate the relationship between estrone levels in women with CVI and healthy women.
Methods: Clinical and laboratory data from 39 women with CVI and 31 healthy women without CVI were collected. All participants underwent spectral Doppler examinations and combined B-mode imaging to assess the severity of CVI.
Results: The results showed a statistically significant increase in the diameter of the vena saphenous magna in the CVI group compared to the healthy control group (p<0.05). However, there were no significant differences in estrone levels between the two groups. Besides, significant correlations were observed between estrone levels and age (r: -0.351; p=0.028), BMI and age(r: 0.374; p=0.019), and BMI and abdominal circumference (r: 0.700; p<0.001) in the CVI group.
Conclusion: Our study suggests that estrone levels may have a protective effect on CVI pathogenesis. The observed effect of estrone on women with CVI may be attributed to its different receptor-level effects compared to estradiol. Further research is necessary to fully elucidate the contribution of estrone to CVI and its underlying mechanisms.

Keywords : Chronic venous insufficiency, estrone, cardioprotective effect, estrogen

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Article available in :
Volume 4, Issue 4, 2023
Page : 302-305
https://doi.org/10.47582/jompac.1322381
Article Information
Received : 04 Tem 2023
Accepted : 07 Ağu 2023
Published : 30 Ağu 2023
Corresponding Author :

Rukiye Ada Bender: Department of Obstetrics and Gynecology, School of Medicine, Biruni University, İstanbul, Turkey

[email protected]
Citation : Bender RA, Şimşek B. The importance of serum estrone level in cases of chronic venous insufficiency in the lower extremity. J Med Palliat Care. 2023;4(4):302-305.

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