JOMPAC
Journal of Medicine and Palliative Care

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

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Original Article
Increased frequency of hypertension and coronary artery disease independent of age in primary hyperparathyroidism associated hypercalcaemia
Abstract
Aims: There are conflicting data in the literature regarding whether there is an increased frequency of coronary artery disease (CAD) in patients with primary hyperparathyroidism (PHP). In this study, we planned to investigate the frequency of CAD and hypertension (HT) in patients with PHP.
Methods: Patients with PHP aged 18 years and older who were admitted to the endocrinology clinic between September 2020 and February 2023 were included as the patient group, and age- and gender-matched individuals who presented with thyroid nodules between the same dates were included as the control group. A total of 217 patients, 114 with PHP and 103 as control group, were eligible for the study. The study was conducted as a retrospective data analysis and laboratory and demographic information of the patients and the control group were obtained from their files.
Results: Age and gender distribution of the patient group and the control group were similar (respectively; age: 55.6+12.9 years, 53.0+7.2 years, p=0.058, female/male distribution: 93/21, 80/23 p=0.48). The prevalence of HT and CAD was higher in the patient group (respectively; HT: 65.1%, 31.0%, p<0.001, CAD: 32.0%, 3.1%, p<0.001), while the prevalence of DM was similar (respectively; 18.1%, 17.3%, p=0.89). The prevalence of HT, CAD and DM was found to be the same among those with mild and severe PHP (respectively; HT: 65.6%, 64.4%, p=0.90, CAD: 38.3%, 23.3%, p=0.14, DM: 19.7%, 15.9%, p=0.62, ). Age (ß=0.10, odds ratio [OR];1.11 [95% confidence interval (95% CI);1.05-1.17], p<0.001) and calcium (ß=0.67, OR;1.96 [95% CI;1.10-3.51], p=0.023) levels were found to be independent effective factors on CAD.
Conclusion: Increased calcium levels in PHP constitute an age-independent risk for CAD. In addition, elevated calcium increases the frequency of HT, which is a CAD risk factor.

Keywords : Primary hyperparathyroidism, hypertension, coronary artery disease, hypercalcaemia

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Article available in :
Volume 4, Issue 4, 2023
Page : 277-282
https://doi.org/10.47582/jompac.1324604
Article Information
Received : 08 Tem 2023
Accepted : 25 Tem 2023
Published : 30 Ağu 2023
Corresponding Author :

Mutlu Güneş: Department of Endocrinology Bursa Yüksek İhtisas Training and Research Hospital, University of Health Sciences, Bursa, Turkey

[email protected]
Citation : Güneş E, Güneş M, Çurgunlu A. Increased frequency of hypertension and coronary artery disease independent of age in primary hyperparathyroidism associated hypercalcaemia. J Med Palliat Care. 2023;4(4):277-282.

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