JOMPAC

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

EndNote Style
Index
Original Article
The severity of COVID-19 infection in children with leukemia
Aims: The coronavirus disease 2019 (COVID-19) has been the cause of a global health crisis since the end of 2019. The aim of this study was to evaluate the clinical findings and treatment results of COVID-19 disease in pediatric patients with leukemia.
Methods: All the children and adolescents with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive real-time polymerase chain reaction (PCR) and the presence of underlying leukemia were included in the study.
Results: A total of 44 leukemia patients with COVID-19 infection were included in the study. Their primary diseases were as follows: 36 patients were newly diagnosed with acute lymphoblastic leukemia (ALL), four patients were relapsed ALL, two patients were refractory ALL, and two patients were acute myeloblastic leukemia. The mean age of patients was 104± 62 months. COVID-19 was asymptomatic in 11.4% of patients, mild in 84%, and moderate in 4.5% whereas none of our patients had a severe infection. No severe complications and/or death were observed in our study group.
Conclusion: It has been found that the clinical course of COVID-19 is mild in children and adolescents with leukemia and undergoing chemotherapy or immunosuppressive therapy.


1. Zhu N, Zhang D, Wang W, et al. A Novel Coronavirus frompatients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-733. doi:10.1056/NEJMoa2001017
2. Al-Qahtani AA. Severe acute respiratory syndrome coronavirus2 (SARS-CoV-2): Emergence, history, basic and clinicalaspects. Saudi J Biol Sci. 2020;27(10):2531-2538. doi:10.1016/j.sjbs.2020.04.033
3. Kannan S, Shaik Syed Ali P, Sheeza A, Hemalatha K.COVID-19 (Novel Coronavirus 2019) - recent trends. EurRev Med Pharmacol Sci. 2020;24(4):2006-2011. doi:10.26355/eurrev_202002_20378
4. Dorantes-Acosta E, Ávila-Montiel D, Klünder-Klünder M, Juárez-Villegas L, Márquez-González H. Survival and complications inpediatric patients with cancer and COVID-19: a meta-analysis.Front Oncol. 2021;10:608282. doi:10.3389/fonc.2020.608282
5. Cuneo A, Scarfò L, Reda G, et al. Chronic lymphocytic leukemiamanagement in Italy during the COVID-19 pandemic: aCampus CLL report. Blood. 2020;136(6):763-766. doi:10.1182/blood.2020006854
6. Huang C, Wang Y, Li X, et al. Clinical features of patientsinfected with 2019 novel coronavirus in Wuhan, China. Lancet.2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5
7. André N, Rouger-Gaudichon J, Brethon B, et al. COVID-19in pediatric oncology from French pediatric oncology andhematology centers: High risk of severe forms?. Pediatr BloodCancer. 2020;67(7):e28392. doi:10.1002/pbc.28392
8. Qatawneh MA, Altarawneh M, Alhazaimeh R, et al.Manifestations of COVID-19 infection in children withmalignancy: A single-center experience in Jordan. World J Virol.2022;11(5):321-330. doi:10.5501/wjv.v11.i5.321
9. Freifeld, A.G., E.J. Bow, K.A. Sepkowitz, et al., Clinical practiceguideline for the use of antimicrobial agents in neutropenicpatients with cancer: 2010 update by the Infectious DiseasesSociety of America. Clin Infect Dis. 2011;52(4):427-431.
10. Ludvigsson JF. Systematic review of COVID-19 in children showsmilder cases and a better prognosis than adults. Acta Paediatr.2020;109(6):1088-1095. doi:10.1111/apa.15270
11. Kebudi R, Kurucu N, Tuğcu D, et al. COVID-19 infection inchildren with cancer and stem cell transplant recipients in Turkey:A nationwide study. Pediatr Blood Cancer. 2021;68(6):e28915.doi:10.1002/pbc.28915
12. Radhakrishnan V, Ovett J, Rajendran A, et al. COVID19 inchildren with cancer in low- and middle-income countries:Experience from a cancer center in Chennai, India. PediatrHematol Oncol. 2021;38(2):161-167. doi:10.1080/08880018.2020.1831113
13. Madhusoodhan PP, Pierro J, Musante J, et al. Characterizationof COVID-19 disease in pediatric oncology patients: The NewYork-New Jersey regional experience. Pediatr Blood Cancer.2021;68(3):e28843. doi:10.1002/pbc.28843
14. de Rojas T, Pérez-Martínez A, Cela E, et al. COVID-19 infectionin children and adolescents with cancer in Madrid. Pediatr BloodCancer. 2020;67(7):e28397. doi:10.1002/pbc.28397
15. Rouger-Gaudichon J, Thébault E, Félix A, et al. Impact of thefirst wave of COVID-19 on pediatric oncology and hematology:a report from the French Society of Pediatric Oncology. Cancers(Basel). 2020;12(11):3398. doi:10.3390/cancers12113398
16. Palomo-Collí MÁ, Fuentes-Lugo AD, Cobo-Ovando SR, Juárez-Villegas L. COVID-19 in children and adolescents with cancerfrom a single center in Mexico City. J Pediatr Hematol Oncol.2021;43(7):e1047-e1048. doi:10.1097/MPH.0000000000002040
17. Lee LY, Cazier JB, Angelis V, et al. COVID-19 mortality in patientswith cancer on chemotherapy or other anticancer treatments: aprospective cohort study [published correction appears in Lancet.2020 Aug 22;396(10250):534]. Lancet. 2020;395(10241):1919-1926. doi:10.1016/S0140-6736(20)31173-9
18. Dong Y, Mo X, Hu Y, et al. Epidemiology of COVID-19among children in China. Pediatrics. 2020;145(6):e20200702.doi:10.1542/peds.2020-0702
19. Boulad F, Kamboj M, Bouvier N, Mauguen A, Kung AL.COVID-19 in children with cancer in New York City. JAMAOncol. 2020;6(9):1459-1460. doi:10.1001/jamaoncol.2020.2028
20. Gampel B, Troullioud Lucas AG, Broglie L, et al. COVID-19disease in New York City pediatric hematology and oncologypatients. Pediatr Blood Cancer. 2020;67(9):e28420. doi:10.1002/pbc.28420
21. Balduzzi A, Brivio E, Rovelli A, et al. Lessons after the earlymanagement of the COVID-19 outbreak in a pediatric transplantand hemato-oncology center embedded within a COVID-19dedicated hospital in Lombardia, Italy. Estote parati. BoneMarrow Transplant. 2020;55(10):1900-1905. doi:10.1038/s41409-020-0895-4
22. Kebudi R, Chantada G, Kurucu N, Tuğcu D, Mukkada S, CMoreira D. COVID-19: consequences for children with cancerin Turkey and Globally. Turk Arch Pediatr. 2021;56(4):295-299.doi:10.5152/TurkArchPediatr.2021.21134
23. Feldstein LR, Rose EB, Horwitz SM, et al. Multisysteminflammatory syndrome in U.S. children and adolescents. N EnglJ Med. 2020;383(4):334-346. doi:10.1056/NEJMoa2021680
24. Dufort EM, Koumans EH, Chow EJ, et al. Multisysteminflammatory syndrome in children in New York State. N Engl JMed. 2020;383(4):347-358. doi:10.1056/NEJMoa2021756
25. Minotti C, Tirelli F, Barbieri E, Giaquinto C, Donà D. How isimmunosuppressive status affecting children and adults in SARS-CoV-2 infection? a systematic review. J Infect. 2020;81(1):e61-e66.doi:10.1016/j.jinf.2020.04.026
26. Sepulveda J, Westblade LF, Whittier S, et al. Bacteremia and bloodculture utilization during COVID-19 surge in New York City. JClin Microbiol. 2020;58(8):e00875-20. doi:10.1128/JCM.00875-20
Volume 4, Issue 4, 2023
Page : 258-262
_Footer