JOMPAC
Journal of Medicine and Palliative Care

Journal of Medicine and Palliative Care (JOMPAC) is an open access scientific journal with independent, unbiased, and double-blind review under international guidelines. The purpose of JOMPAC is to contribute to the literature by publishing articles on health sciences and medicine.

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Original Article
Monocyte-to-HDL-cholesterol as a predictor of disease severity in acute pancreatitis
Abstract
Aims: Acute pancreatitis is an inflammatory process of the pancreas that can affect local tissues or distant organ systems. Recent studies have described the monocyte count to high density lipoprotein (HDL) cholesterol ratio (MHR) as a significant prognostic marker. The aim of this study was to investigate the relationship between the MHR and disease severity in patients diagnosed with AP.
Methods: One hundred sixty-six AP patients were enrolled in this study. MHR and inflammatory parameters were measured for all study participants. Disease severity was measured using the Ranson score on admission, and cases were classified as mild or severe AP. MHR was then compared between the groups.
Results: MHR values were significantly higher in severe AP patients (25.2, range 7.89-77.8) compared with mild AP patients (14.32, range 0.71-80) (P=0.006). Based on the Ranson criteria, the overall accuracy of MHR in determining severe AP was sensitivity 72.7% and specificity 69% (AUC: 0.762; P=0.006). The overall accuracy of MHR in predicting disease severity was superior to other inflammatory markers.
Conclusion: The study findings indicated that MHR values are significantly elevated and capable of use in determining disease severity in AP patients.

Keywords : Monocyte, HDL, MHR, ranson, inflammation

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Article available in :
Volume 4, Issue 3, 2023
Page : 196-200
https://doi.org/10.47582/jompac.1261852
Article Information
Received : 08 Mar 2023
Accepted : 02 May 2023
Published : 28 Haz 2023
Corresponding Author :

Ruhsen Özçağlayan: Department of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California, USA

[email protected]
Citation : Özçağlayan R, Önmez A. Monocyte-to-HDL-cholesterol as a predictor of disease severity in acute pancreatitis. J Med Palliat Care. 2023;4(3):196-200.

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